Pharmaceutical Name: Dianabol
Chemical Name: Methandienone
Molecular Structure: C20H28O2
Molecular Weight: 300.4
INN active substance: Methandienone
1 tablet contains:
active substance: methandienone 10 mg or 50 mg;
Other ingredients: magnesium stearate, ludipressÒ (lactose, povidone, crospovidone).
Methandienone is an anabolic steroid. Getting Inside the cell nucleus, stimulates the genetic apparatus of the cell, leading to increased synthesis of DNA, RNA and structural proteins, active enzymes chain breathing tissue and enhancing breathing tissue oxidative phosphorylation, ATP synthesis and assembly of intracellular macroergic . Stimulates anabolic processes and inhibits their catabolic those caused by glucocorticoids. Leads to increased muscle mass, reducing fat deposits, improves trophic tissues, promote calcium deposition in bones, retains nitrogen, phosphorus, sulfur, potassium, sodium and water in the body. Hematopoietic action of erythropoietin is determined by increased synthesis. Androgenic action (moderate) may contribute to the development of male secondary sexual characteristics type.
It is rapidly and completely absorbed in TGI, low bioavailability is determined by the presence of the effect of pass through first-pass metabolism. Are attached to the carriers according to the specific globulin 90%. It is subject to final biotransformation in the liver to form inactive metabolites. It is renally excreted.
Duration – up to 14 hours.
Protein synthesis disorders, cachexia diverse genesis; trauma, burns, pre- and postoperative irradiation after infectious diseases; renal and adrenal insufficiency, toxic goiter, muscular dystrophy, osteoporosis, balance nitrate negative corticosteroid therapy, aplastic anemia and hypo-. Adjuvant in the treatment of tuberculosis, osteomyelitis, asthma, hepatitis.
DOSAGE AND METHOD OF ADMINISTRATION
Adults – starting dose 10-20 mg / day. The maintenance dose is 5-10 mg / day. The maximum dose – 50 mg / 24 hours.
Children: up to 2 years – 0.04 mg / kg; 2-6 years – 0.5 mg / kg; 6-14 – 1 mg / kg in 1-2 doses. The cure – up to 4 weeks. Clean repeated – over 6-8 weeks.
In women – virilizing symptoms, inhibition of ovarian function, menstrual disorders, hypercalcemia.
In men: in prepubertal – virilising symptoms, idiopathic skin hyperpigmentation, withholding or stopping growth (calcification of epiphyseal growth zones tubular bones); during postpubertary – bladder irritation, gynaecomastia, priapism; the elderly – hypertrophy and / or prostatic carcinoma.
Men and women – the progression of atherosclerosis, peripheral edema, impaired liver function with jaundice, changes in blood count, long tubular bones pain, hipocoagulare prone to bleeding.
Hypersensitivity to the drug, prostate cancer, breast cancer in men, breast carcinoma in women with hypercalcemia, CPI, severe atherosclerosis, hepatic and renal failure, and chronic acute prostatitis, pregnancy and lactation.
Cases of overdose have not been reported.
WARNINGS AND SPECIAL PRECAUTIONS FOR USE
Children are recommended after one month of treatment, rest for 1-2 months.
At the first signs of virilization of patients (deepening of the voice, hirsutism, acne, clitoromegalie) administration must be stopped to avoid irreversible changes. It is lipidemia systematically control and cholesterol.
Interactions with other drugs
Increase the action of anticoagulants, antiplatelet, hypoglycemic remedies, as potentiate the side effects of hepatotoxic remedies.
Store in a dry, dark place at a temperature of 15-25 ° C.
Keep out of reach of children.
TERMS OF VALIDITY
3 years. Do not use after expiration date indicated on the packaging.